The fuel consumption of the Lexus V6 engine, particularly in the 2025 Lexus ES 350 with the 3.5-liter V6, showcases impressive efficiency for its class. In a real-world highway test, the ES 350 achieved an average of 38.2 miles per gallon (mpg) over a 114-mile loop at highway speeds, surpassing its EPA highway rating of 32 mpg. During the drive, the onboard computer displayed an average between 34.2 and 35.6 mpg, but manual calculations at the pump confirmed the higher figure[1].
This performance is notable for a naturally aspirated, 302-horsepower, 3.5-liter V6 equipped with an 8-speed automatic transmission. Under typical conditions and according to manufacturer specifications, drivers should expect approximately 32 mpg on the highway and somewhat lower figures in the city, depending on driving style and conditions[2][3].